How to beat Ramon Salazar in Resident Evil 4 Remake: Boss fight guide

Defeating Ramon Salazar in Resident Evil 4 Remake can be extremely challenging, so we’ve put together everything that you need to do in order to come out victorious in this battle.

As you progress through the lengthy story of Resident Evil 4 Remake, you’ll collect a ton of deadly weapons and items as you prepare for battle against hoards of enemies in each new chapter.

One of the most challenging encounters in the game is the battle against Ramon Salazar in Chapter 12. This dangerous opponent will not go down easy, and we’ll break down exactly how you can defeat him in Resident Evil 4 Remake.

How to prepare for the Ramon Salazar fight in Resident Evil 4 Remake

We recommend acquiring automatic and semi-automatic weapons such as the TMP and Stingray for this fight. This is because using a gun with a fast fire rate will make it easier to hit Salazar while he’s moving.

You should also stock up on healing items as Ramon Salazar has extremely deadly attacks that can take you down fast. You can acquire these items from the Merchant in Resident Evil 4 Remake.

How to defeat Ramon Salazar in Resident Evil 4 Remake

Throughout this fight, Salazar’s body will be protected by the monster’s mouth, and you’ll have the opportunity to shoot at it whenever the creature spits acid. After it takes enough damage, Salazar’s body will have a melee prompt for you to dish out more damage.

Here’s what you need to do:

1. Shoot at the monster whenever it spits acid.
2. Wait until Salazar’s body drops.
3. Go up to Salazar and press the melee prompt to deal damage.
4. Keep firing while avoiding his attacks.

Salazar will hit you with a ton of deadly attacks, including acid spit and acid pods which can quickly reduce your health if you get caught. The attack you should be most careful about is when the monster tries to chomp you, as this can instantly kill you.

You can evade these attacks effectively if you take cover behind the staircase with a pillar. The acid pods also drop useful loot when you shoot at them, but be sure to keep your distance when they explode.

Just keep this up and eventually, you’ll defeat Salazar. Once this is done, you’ll get the “No Thanks, Bro!” achievement. You can also get the “You Talk Too Much!” achievement if you landed a grenade into Salazar’s mouth during the fight.

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For more Resident Evil 4 Remake content, also check out our other helpful guides below:

Where to find all Resident Evil 4 Remake Blue Medallions | Does Resident Evil 4 Remake have multiplayer or co-op? | Is Resident Evil 4 Remake on Steam Deck? | Resident Evil 4 Remake pre-order bonuses: All editions & prices | What are Spinels in Resident Evil 4 Remake? | Resident Evil 4 Remake treasure combinations & Gemstone reward bonuses explained

Image Credits: Capcom